Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models

Author:

Hotz Christian1ORCID,Wagenaar Timothy R.2ORCID,Gieseke Friederike1ORCID,Bangari Dinesh S.2ORCID,Callahan Michelle2ORCID,Cao Hui2,Diekmann Jan1,Diken Mustafa13,Grunwitz Christian1,Hebert Andy2,Hsu Karl2ORCID,Bernardo Marie2,Karikó Katalin1ORCID,Kreiter Sebastian13ORCID,Kuhn Andreas N.1,Levit Mikhail2ORCID,Malkova Natalia2,Masciari Serena2,Pollard Jack2ORCID,Qu Hui2,Ryan Sue2ORCID,Selmi Abderaouf3,Schlereth Julia1,Singh Kuldeep2ORCID,Sun Fangxian2,Tillmann Bodo3,Tolstykh Tatiana2,Weber William2ORCID,Wicke Lena1,Witzel Sonja3ORCID,Yu Qunyan2ORCID,Zhang Yu-An2ORCID,Zheng Gang2,Lager Joanne2ORCID,Nabel Gary J.2ORCID,Sahin Ugur13ORCID,Wiederschain Dmitri2

Affiliation:

1. BioNTech, 55131 Mainz, Germany.

2. Research and Development, Sanofi, Cambridge, MA 02139, USA.

3. Translational Oncology at the University Medical Center of Johannes Gutenberg University GmbH (TRON), 55131 Mainz, Germany.

Abstract

Local immunotherapy with an mRNA mixture encoding four cytokines mobilizes a systemic antitumor response and promotes tumor eradication.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Cited by 111 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3