Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models-Reference-Cited by-同舟云学术

Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models

Published:2021-09-08 Issue:610 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hotz Christian¹^ORCID,Wagenaar Timothy R.²^ORCID,Gieseke Friederike¹^ORCID,Bangari Dinesh S.²^ORCID,Callahan Michelle²^ORCID,Cao Hui²,Diekmann Jan¹,Diken Mustafa¹³,Grunwitz Christian¹,Hebert Andy²,Hsu Karl²^ORCID,Bernardo Marie²,Karikó Katalin¹^ORCID,Kreiter Sebastian¹³^ORCID,Kuhn Andreas N.¹,Levit Mikhail²^ORCID,Malkova Natalia²,Masciari Serena²,Pollard Jack²^ORCID,Qu Hui²,Ryan Sue²^ORCID,Selmi Abderaouf³,Schlereth Julia¹,Singh Kuldeep²^ORCID,Sun Fangxian²,Tillmann Bodo³,Tolstykh Tatiana²,Weber William²^ORCID,Wicke Lena¹,Witzel Sonja³^ORCID,Yu Qunyan²^ORCID,Zhang Yu-An²^ORCID,Zheng Gang²,Lager Joanne²^ORCID,Nabel Gary J.²^ORCID,Sahin Ugur¹³^ORCID,Wiederschain Dmitri²

Affiliation:

1. BioNTech, 55131 Mainz, Germany.

2. Research and Development, Sanofi, Cambridge, MA 02139, USA.

3. Translational Oncology at the University Medical Center of Johannes Gutenberg University GmbH (TRON), 55131 Mainz, Germany.

Abstract

Local immunotherapy with an mRNA mixture encoding four cytokines mobilizes a systemic antitumor response and promotes tumor eradication.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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