The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography

Author:

Sanchez Justin S.123ORCID,Becker J. Alex123ORCID,Jacobs Heidi I. L.1234ORCID,Hanseeuw Bernard J.1235,Jiang Shu67ORCID,Schultz Aaron P.12,Properzi Michael J.12,Katz Samantha R.123ORCID,Beiser Alexa8910ORCID,Satizabal Claudia L.81011ORCID,O’Donnell Adrienne910ORCID,DeCarli Charles12,Killiany Ron89ORCID,El Fakhri Georges123,Normandin Marc D.123ORCID,Gómez-Isla Teresa12,Quiroz Yakeel T.1213ORCID,Rentz Dorene M.1214ORCID,Sperling Reisa A.1214,Seshadri Sudha81011ORCID,Augustinack Jean12,Price Julie C.12,Johnson Keith A.12314ORCID

Affiliation:

1. Massachusetts General Hospital, Boston, MA 02114, USA.

2. Harvard Medical School, Boston, MA 02115, USA.

3. Gordon Center for Medical Imaging, Boston, MA, 02114, USA.

4. School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, 6211 LK, Netherlands.

5. Université Catholique de Louvain, Brussels B-1348, Belgium.

6. Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

7. Washington University School of Medicine, St. Louis, MO 63110, USA.

8. Boston University School of Medicine, Boston, MA 02118, USA.

9. Boston University School of Public Health, Boston, MA 02118, USA.

10. Framingham Heart Study, Framingham, MA 01702, USA.

11. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA.

12. University of California, Davis, Davis, CA 95616, USA.

13. Grupo de Neurociencias, Universidad de Antioquia, Antioquia 050010, Colombia.

14. Brigham and Women’s Hospital, Boston, MA 02115, USA.

Abstract

An automated method to quantify TAU PET detected initial cortical tauopathy in Alzheimer’s disease and tracked subsequent amyloid-related TAU spread.

Funder

U.S. Department of Health and Human Services

National Institute on Aging

NIH Office of the Director

National Institute of Biomedical Imaging and Bioengineering

National Heart, Lung, and Blood Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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