Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice-Reference-Cited by-同舟云学术

Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice

Published:2020-11-18 Issue:570 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hsieh Lawrence S.¹^ORCID,Wen John H.¹,Nguyen Lena H.¹^ORCID,Zhang Longbo¹²^ORCID,Getz Stephanie A.¹^ORCID,Torres-Reveron Juan¹^ORCID,Wang Ying³^ORCID,Spencer Dennis D.¹,Bordey Angélique¹⁴^ORCID

Affiliation:

1. Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

2. Department of Neurosurgery, Xiangya Hospital, Xiangya Hospital, Central South University, 87 Xiangya Street, Changsha, Hunan 410008, China.

3. Emergency Department, Xiangya Hospital, Central South University, 87 Xiangya Street, Changsha, Hunan 410008, China.

4. Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

Abstract

A cAMP-dependent mechanism mediates seizures in mTOR disorders due to the ectopic expression of HCN4 channels in diseased neurons.

Funder

U.S. Department of Defense

American Epilepsy Society

National Natural Science Foundation of China

NIH/NINDS

NIH/NICHD

Swebilius Foundation

Brown Coxe

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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