Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer-Reference-Cited by-同舟云学术

Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer

Published:2021-03-03 Issue:583 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wu Heng-Hsiung¹²^ORCID,Tsai Lung-Hung¹,Huang Chun-Kai³,Hsu Pang-Hung⁴⁵^ORCID,Chen Mei-Yu¹,Chen Yi-Ing³^ORCID,Hu Chun-Mei³^ORCID,Shen Chia-Ning³^ORCID,Lee Chen-Chen¹⁶^ORCID,Chang Ming-Chu⁷,Chang Yu-Ting⁷,Tien Yu-Wen⁸^ORCID,Jeng Yung-Ming⁹,Lee Eva Y.-H. P.³¹⁰,Lee Wen-Hwa¹³¹⁰^ORCID

Affiliation:

1. Drug Development Center, China Medical University, Taichung 40402, Taiwan.

2. Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.

3. Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.

4. Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 11221, Taiwan.

5. Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20224, Taiwan.

6. Department of Microbiology and Immunology, China Medical University, Taichung 40402, Taiwan.

7. Department of Internal Medicine, National Taiwan University Hospital, Taipei 10041, Taiwan.

8. Department of Surgery, National Taiwan University Hospital, Taipei 10041, Taiwan.

9. Department of Pathology, National Taiwan University Hospital, Taipei 10041, Taiwan.

10. Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.

Abstract

Blocking MLK4-mediated IL-17RB phosphorylation diminishes downstream signaling and suppresses pancreatic cancer progression and metastasis.

Funder

Academia Sinica

Ministry of Science and Technology, Taiwan

China Medical University

Ministry of Education (MOE), Taiwan

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

1. Functional Specialization of Interleukin-17 Family Members

2. IL-17: Prototype member of an emerging cytokine family;Aggarwal S.;J. Leukoc. Biol.,2002

3. The STIR-domain superfamily in signal transduction, development and immunity

4. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

5. Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. TCF3 as a multidimensional biomarker: oncogenicity, genomic alterations, and immune landscape in pan-cancer analysis;Acta Biochimica et Biophysica Sinica;2024-08-01

2. Endometrial senescence is mediated by interleukin 17 receptor B signaling;Cell Communication and Signaling;2024-07-15

3. TRIM37 maintains 5hmC levels and stemness through preventing DNMT1 alternative splicing;2024-03-20

4. Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB pathway in injured peripheral nerves;Cell Reports;2024-02

5. Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy;Nature Cancer;2024-01-24