Down-regulation of A20 promotes immune escape of lung adenocarcinomas

Author:

Breitenecker Kristina123ORCID,Homolya Monika1ORCID,Luca Andreea C.1ORCID,Lang Veronika1ORCID,Trenk Christoph1ORCID,Petroczi Georg1ORCID,Mohrherr Julian1,Horvath Jaqueline1ORCID,Moritsch Stefan23ORCID,Haas Lisa4,Kurnaeva Margarita1ORCID,Eferl Robert23ORCID,Stoiber Dagmar15ORCID,Moriggl Richard6ORCID,Bilban Martin78ORCID,Obenauf Anna C.4ORCID,Ferran Christiane910ORCID,Dome Balazs111213ORCID,Laszlo Viktoria1112ORCID,Győrffy Balázs141516,Dezso Katalin17ORCID,Moldvay Judit1819ORCID,Casanova Emilio13ORCID,Moll Herwig P.13ORCID

Affiliation:

1. Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, AT-1090 Vienna, Austria.

2. Institute of Cancer Research, Medical University of Vienna, AT-1090 Vienna, Austria

3. Comprehensive Cancer Center (CCC), Medical University of Vienna, AT-1090 Vienna, Austria.

4. Research Institute of Molecular Pathology, Vienna Biocenter, AT-1030 Vienna, Austria.

5. Division Pharmacology, Department of Pharmacology, Physiology and Microbiology, Karl Landsteiner University of Health Sciences, AT-3500 Krems, Austria.

6. Institute of Animal Breeding and Genetics, University of Veterinary Medicine, AT-1210 Vienna, Austria.

7. Department of Laboratory Medicine, Medical University of Vienna, AT-1090 Vienna, Austria.

8. Core Facilities, Medical University of Vienna, AT-1090 Vienna, Austria.

9. Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

10. Transplant Institute and the Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

11. Division of Thoracic Surgery, Department of Surgery, and Comprehensive Cancer Center (CCC), Medical University of Vienna, AT-1090 Vienna, Austria.

12. 1st Department of Tumor Biology, National Korányi Institute of Pulmonology, Semmelweis University, HU-1121 Budapest, Hungary.

13. Department of Thoracic Surgery, National Institute of Oncology and Semmelweis University, HU-1122 Budapest, Hungary.

14. MTA TTK Lendület Cancer Biomarker Research Group, Institute of Enzymology, and 2nd Department of Pediatrics, Semmelweis University, HU-1117 Budapest, Hungary.

15. Department of Bioinformatics, Semmelweis University, HU-1094 Budapest, Hungary.

16. 2nd Department of Pediatrics, Semmelweis University, HU-1094 Budapest, Hungary.

17. 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, HU-1085 Budapest, Hungary.

18. 1st Department of Pulmonology, National Korányi Institute of Pulmonology, HU-1121 Budapest, Hungary.

19. SE-NAP Brain Metastasis Research Group, 2nd Department of Pathology, Semmelweis University, HU-1122 Budapest, Hungary.

Abstract

A20 represents an immune checkpoint in lung adenocarcinomas, and its loss may be compensated by targeting the TBK1–STAT1–PD-L1 axis.

Funder

Austrian Science Fund

National Research, Development and Innovation Office, Hungary

Initiative Krebsforschung

Fellinger Krebsforschung

Hungarian NRDI Office

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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