Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8 + T cells drive gastrointestinal acute graft-versus-host disease

Author:

Tkachev Victor1ORCID,Kaminski James12ORCID,Potter E. Lake3ORCID,Furlan Scott N.4,Yu Alison1,Hunt Daniel J.1,McGuckin Connor1ORCID,Zheng Hengqi5ORCID,Colonna Lucrezia4,Gerdemann Ulrike1ORCID,Carlson Judith5,Hoffman Michelle4ORCID,Olvera Joe1ORCID,English Chris6ORCID,Baldessari Audrey6ORCID,Panoskaltsis-Mortari Angela7ORCID,Watkins Benjamin8ORCID,Qayed Muna8,Suessmuth Yvonne8,Betz Kayla1,Bratrude Brandi1ORCID,Langston Amelia8ORCID,Horan John T.8,Ordovas-Montanes Jose2910ORCID,Shalek Alex K.21112ORCID,Blazar Bruce R.7ORCID,Roederer Mario3ORCID,Kean Leslie S.1ORCID

Affiliation:

1. Division of Pediatric Hematology/Oncology, Boston Children’s Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

2. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

3. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20858, USA.

4. Fred Hutchinson Cancer Research Center, Department of Pediatrics, University of Washington, Seattle, WA 98109, USA.

5. University of Washington, Seattle, WA 98195, USA.

6. Washington National Primate Research Center, Seattle, WA 98195, USA.

7. Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55454, USA.

8. Emory University School of Medicine, Atlanta, GA 30322, USA.

9. Division of Gastroenterology, Boston Children’s Hospital and Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.

10. Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

11. Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02142, USA.

12. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

Abstract

Flow cytometric and transcriptomic analyses reveal coordinated tissue infiltration and tissue residence of donor T cells that drive gastrointestinal GVHD.

Funder

American Cancer Society

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

Alfred P. Sloan Foundation

Be The Match Foundation

American Society for Transplantation and Cellular Therapy

Richard and Susan Smith Family Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3