A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma-Reference-Cited by-同舟云学术

A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma

Published:2021-05-05 Issue:592 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Konduri Vanaja¹^ORCID,Joseph Sujith K.²³^ORCID,Byrd Tiara T.²³^ORCID,Nawas Zeid²³^ORCID,Vazquez-Perez Jonathan¹^ORCID,Hofferek Colby J.¹^ORCID,Halpert Matthew M.¹^ORCID,Liu Dongliang⁴,Liang Zhengdong⁴^ORCID,Baig Yunyu¹^ORCID,Salsman Vita S.²³,Oyewole-Said Damilola¹^ORCID,Tsimelzon Anna⁵,Burns Briana A.¹^ORCID,Chen Changyi⁴⁶,Levitt Jonathan M.¹⁵⁷,Yao Qizhi¹⁴⁸⁹^ORCID,Ahmed Nabil M.²³⁸^ORCID,Hegde Meenakshi²³⁸,Decker William K.¹²⁸^ORCID

Affiliation:

1. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.

2. Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.

3. Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA.

4. Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.

5. Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.

6. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

7. Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA.

8. Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

9. Michael E. DeBakey VA Medical Center, Center for Translational Research on Inflammatory Diseases (CTRID), Houston, TX 77030, USA.

Abstract

A highly cytotoxic T cell memory subset demonstrates intrinsic advantages when used as a CAR T cell platform in a solid tumor model.

Funder

National Institutes of Health

National Cancer Institute

National Institute of Allergy and Infectious Diseases

National Center for Research Resources

Alex’s Lemonade Stand Foundation for Childhood Cancer

St. Baldrick’s Foundation

Stand Up To Cancer

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

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