CNS therapeutics: Immune cells break the barriers-Reference-Cited by-同舟云学术

CNS therapeutics: Immune cells break the barriers

Published:2023-11-08 Issue:721 Volume:15 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Thai Karine¹²^ORCID,Prat Alexandre¹²³^ORCID

Affiliation:

1. Neuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC H2X 0A9, Canada.

2. Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.

3. Multiple Sclerosis Clinic, Division of Neurology, Centre Hospitalier de l’Université de Montréal (CHUM), Montreal, QC H2L 4M1, Canada.

Abstract

Peripheral immune cells can be seen as attractive vectors and drug carriers for central nervous system therapeutics because these cells have unique properties that allow them to migrate across the blood-brain barrier, enabling drug delivery to brain regions that are inaccessible to free drugs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Link

https://www.science.org/doi/pdf/10.1126/scitranslmed.adh1150

Reference26 articles.

1. Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

2. Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma

3. Differences in P-glycoprotein activity in human and rodent blood–brain barrier assessed by mechanistic modelling

4. B7 Expression and Antigen Presentation by Human Brain Endothelial Cells: Requirement for Proinflammatory Cytokines

5. A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis