Prospective study design and data analysis in UK Biobank

Author:

Allen Naomi E.12ORCID,Lacey Ben12ORCID,Lawlor Deborah A.34,Pell Jill P.5,Gallacher John67ORCID,Smeeth Liam8ORCID,Elliott Paul910ORCID,Matthews Paul M.11ORCID,Lyons Ronan A.12ORCID,Whetton Anthony D.13ORCID,Lucassen Anneke1415ORCID,Hurles Matthew E.16ORCID,Chapman Michael17ORCID,Roddam Andrew W.18,Fitzpatrick Natalie K.19ORCID,Hansell Anna L.20ORCID,Hardy Rebecca21ORCID,Marioni Riccardo E.22ORCID,O’Donnell Valerie B.23ORCID,Williams Julie24ORCID,Lindgren Cecilia M.25,Effingham Mark1ORCID,Sellors Jonathan1ORCID,Danesh John262728,Collins Rory12ORCID

Affiliation:

1. UK Biobank Ltd, Stockport, UK.

2. Nuffield Department of Population Health, University of Oxford, Oxford, UK.

3. Population Health Science, Bristol Medical School University of Bristol, Bristol, UK.

4. Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.

5. School of Health and Wellbeing, University of Glasgow, Scotland.

6. Department of Psychiatry, University of Oxford, Oxford, UK.

7. Dementias Platform UK, Department of Psychiatry, University of Oxford, Oxford, UK.

8. London School of Hygiene and Tropical Medicine, London, UK.

9. MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.

10. NIHR Health Protection Research Unit in Chemical Radiation Threats and Hazards, Imperial College London, UK.

11. UK Dementia Research Centre Institute and Department of Brain Sciences, Imperial College London, London, UK.

12. Population Data Science, Swansea University Medical School, Swansea, Wales.

13. Veterinary Health Innovation Engine, University of Surrey, Guildford, UK.

14. Nuffield Department of Medicine, University of Oxford, Oxford, UK.

15. Faculty of Medicine, Southampton University, Southampton, UK.

16. Wellcome Trust Sanger Institute, Wellcome Genome Campus, Cambridge, UK.

17. NHS England, London, UK.

18. Our Future Health, London, UK.

19. Institute of Health Informatics, University College London, London, UK.

20. Centre for Environmental Health and Sustainability, University of Leicester, Leicester, UK.

21. School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.

22. Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, Scotland.

23. School of Medicine, Cardiff University, Cardiff, Wales.

24. UK Dementia Research Institute, Cardiff University, Cardiff, Wales.

25. Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.

26. British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

27. Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.

28. National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.

Abstract

Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank’s study design, data access policies, and approaches to statistical analysis can help to minimize error and improve the interpretability of research findings, with implications for other population-based prospective studies being established worldwide.

Publisher

American Association for the Advancement of Science (AAAS)

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