Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

Author:

Julg Boris12ORCID,Tartaglia Lawrence J.2ORCID,Keele Brandon F.3ORCID,Wagh Kshitij4,Pegu Amarendra5ORCID,Sok Devin6ORCID,Abbink Peter2ORCID,Schmidt Stephen D.5ORCID,Wang Keyun5,Chen Xuejun5ORCID,Joyce M. Gordon5ORCID,Georgiev Ivelin S.5,Choe Misook5ORCID,Kwong Peter D.5ORCID,Doria-Rose Nicole A.5ORCID,Le Khoa6ORCID,Louder Mark K.5ORCID,Bailer Robert T.5,Moore Penny L.78ORCID,Korber Bette4ORCID,Seaman Michael S.2ORCID,Abdool Karim Salim S.89ORCID,Morris Lynn78ORCID,Koup Richard A.5,Mascola John R.5ORCID,Burton Dennis R.16ORCID,Barouch Dan H.12ORCID

Affiliation:

1. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.

2. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

3. AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

4. Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

5. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.

6. The Scripps Research Institute, La Jolla, CA 92037, USA.

7. National Institute for Communicable Diseases of the National Health Laboratory Service and the University of the Witwatersrand, 2131 Johannesburg, South Africa.

8. Centre for the AIDS Programme of Research in South Africa, 4013 Durban, South Africa.

9. Columbia University, New York, NY 10032, USA.

Abstract

Neutralizing antibodies to the HIV-1 envelope V2 apex protect macaques against SHIV challenge at very low serum concentrations.

Funder

National Institute of Allergy and Infectious Diseases

amfAR

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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