Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief-Reference-Cited by-同舟云学术

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Published:2017-05-31 Issue:392 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Jensen Dane D.¹²^ORCID,Lieu TinaMarie¹²^ORCID,Halls Michelle L.¹^ORCID,Veldhuis Nicholas A.¹²,Imlach Wendy L.³^ORCID,Mai Quynh N.¹²^ORCID,Poole Daniel P.¹²^ORCID,Quach Tim¹²^ORCID,Aurelio Luigi¹²,Conner Joshua¹²^ORCID,Herenbrink Carmen Klein¹²,Barlow Nicholas¹,Simpson Jamie S.¹^ORCID,Scanlon Martin J.¹^ORCID,Graham Bimbil¹,McCluskey Adam⁴^ORCID,Robinson Phillip J.⁵^ORCID,Escriou Virginie⁶,Nassini Romina⁷^ORCID,Materazzi Serena⁷,Geppetti Pierangelo⁷,Hicks Gareth A.⁸,Christie Macdonald J.³^ORCID,Porter Christopher J. H.¹²^ORCID,Canals Meritxell¹²^ORCID,Bunnett Nigel W.¹²⁹¹⁰^ORCID

Affiliation:

1. Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

2. Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia.

3. Discipline of Pharmacology, University of Sydney, New South Wales 2006, Australia.

4. School of Environmental and Life Sciences, University of Newcastle, New South Wales 2308, Australia.

5. Children’s Medical Research Institute, University of Sydney, New South Wales 2145, Australia.

6. Unité de Technologies Chimiques et Biologiques pour la Sante, CNRS UMR8258, INSERM U1022, Université Paris Descartes, Chimie ParisTech, 75006 Paris, France.

7. Department of Health Sciences, Clinical Pharmacology Unit, University of Florence, 6-50139 Florence, Italy.

8. Takeda Pharmaceuticals, Boston, MA 02139, USA.

9. Department of Pharmacology and Therapeutics, University of Melbourne, Victoria 3010, Australia.

10. Departments of Surgery and Pharmacology, Columbia University College of Physicians and Surgeons, Columbia University, 21 Audubon Avenue, Room 209, New York City, NY 10032, USA.

Abstract

Therapeutic targeting of the neurokinin 1 receptor in endosomes provides efficacious and prolonged pain relief.

Funder

National Health and Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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