Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Author:

Jensen Dane D.12ORCID,Lieu TinaMarie12ORCID,Halls Michelle L.1ORCID,Veldhuis Nicholas A.12,Imlach Wendy L.3ORCID,Mai Quynh N.12ORCID,Poole Daniel P.12ORCID,Quach Tim12ORCID,Aurelio Luigi12,Conner Joshua12ORCID,Herenbrink Carmen Klein12,Barlow Nicholas1,Simpson Jamie S.1ORCID,Scanlon Martin J.1ORCID,Graham Bimbil1,McCluskey Adam4ORCID,Robinson Phillip J.5ORCID,Escriou Virginie6,Nassini Romina7ORCID,Materazzi Serena7,Geppetti Pierangelo7,Hicks Gareth A.8,Christie Macdonald J.3ORCID,Porter Christopher J. H.12ORCID,Canals Meritxell12ORCID,Bunnett Nigel W.12910ORCID

Affiliation:

1. Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

2. Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia.

3. Discipline of Pharmacology, University of Sydney, New South Wales 2006, Australia.

4. School of Environmental and Life Sciences, University of Newcastle, New South Wales 2308, Australia.

5. Children’s Medical Research Institute, University of Sydney, New South Wales 2145, Australia.

6. Unité de Technologies Chimiques et Biologiques pour la Sante, CNRS UMR8258, INSERM U1022, Université Paris Descartes, Chimie ParisTech, 75006 Paris, France.

7. Department of Health Sciences, Clinical Pharmacology Unit, University of Florence, 6-50139 Florence, Italy.

8. Takeda Pharmaceuticals, Boston, MA 02139, USA.

9. Department of Pharmacology and Therapeutics, University of Melbourne, Victoria 3010, Australia.

10. Departments of Surgery and Pharmacology, Columbia University College of Physicians and Surgeons, Columbia University, 21 Audubon Avenue, Room 209, New York City, NY 10032, USA.

Abstract

Therapeutic targeting of the neurokinin 1 receptor in endosomes provides efficacious and prolonged pain relief.

Funder

National Health and Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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