Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase-Reference-Cited by-同舟云学术

Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase

Published:2017-06-07 Issue:393 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ziegler Shira G.¹^ORCID,Ferreira Carlos R.²,MacFarlane Elena Gallo¹^ORCID,Riddle Ryan C.³⁴^ORCID,Tomlinson Ryan E.³,Chew Emily Y.⁵^ORCID,Martin Ludovic⁶,Ma Chen-Ting⁷,Sergienko Eduard⁷,Pinkerton Anthony B.⁷^ORCID,Millán José Luis⁷,Gahl William A.²^ORCID,Dietz Harry C.¹⁸^ORCID

Affiliation:

1. Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2. Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20814, USA.

3. Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4. Baltimore Veterans Administrations Medical Center, Baltimore, MD 21201, USA.

5. National Eye Institute, National Institutes of Health, Bethesda, MD 20814, USA.

6. PXE Reference Center and MitoVasc Institute, Angers University Hospital, Angers, France.

7. Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.

8. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Abstract

Ectopic calcification in PXE integrates both local and systemic perturbations of extracellular ATP metabolism and can be attenuated with a TNAP inhibitor.

Funder

National Institutes of Health

Howard Hughes Medical Institute

National Human Genome Research Institute

Johns Hopkins University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

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