Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

Author:

Yang Katherine S.12ORCID,Im Hyungsoon12ORCID,Hong Seonki12ORCID,Pergolini Ilaria3,del Castillo Andres Fernandez1ORCID,Wang Rui45ORCID,Clardy Susan12,Huang Chen-Han12,Pille Craig16ORCID,Ferrone Soldano3,Yang Robert1,Castro Cesar M.17ORCID,Lee Hakho12,del Castillo Carlos Fernandez37,Weissleder Ralph128ORCID

Affiliation:

1. Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

2. Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

3. Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

4. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

5. Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.

6. Department of Health Sciences, Northeastern University, Boston, MA 02115, USA.

7. Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

8. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

A multiplexed plasmonic assay analyzes circulating tumor-derived extracellular vesicles for detection of pancreatic ductal adenocarcinoma.

Funder

National Heart, Lung, and Blood Institute

National Cancer Institute

Lustgarten Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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