HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase-Reference-Cited by-同舟云学术

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase

Published:2017-07-12 Issue:398 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chakraborty Abhishek A.¹^ORCID,Nakamura Eijiro¹,Qi Jun¹^ORCID,Creech Amanda²^ORCID,Jaffe Jacob D.²^ORCID,Paulk Joshiawa¹,Novak Jesse S.¹³,Nagulapalli Kshithija⁴,McBrayer Samuel K.¹,Cowley Glenn S.²^ORCID,Pineda Javier¹,Song Jiaxi¹³,Wang Yaoyu E.⁴,Carr Steven A.²,Root David E.²,Signoretti Sabina¹³,Bradner James E.¹^ORCID,Kaelin William G.¹²⁵⁶^ORCID

Affiliation:

1. Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA.

2. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

3. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

4. Center for Cancer Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

5. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

6. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Abstract

Dysregulated H3K27 demethylase activity in pVHL-deficient cells increases dependence on the EZH1 H3K27 methyltransferase.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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