Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis-Reference-Cited by-同舟云学术

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

Published:2017-12-13 Issue:420 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lagares David¹^ORCID,Santos Alba¹^ORCID,Grasberger Paula E.¹^ORCID,Liu Fei²^ORCID,Probst Clemens K.¹^ORCID,Rahimi Rod A.¹^ORCID,Sakai Norihiko¹³,Kuehl Tobias¹,Ryan Jeremy⁴^ORCID,Bhola Patrick⁴,Montero Joan⁴,Kapoor Mohit⁵^ORCID,Baron Murray⁶^ORCID,Varelas Xaralabos⁷,Tschumperlin Daniel J.²⁸^ORCID,Letai Anthony⁴,Tager Andrew M.¹

Affiliation:

1. Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

2. Molecular and Integrative Physiological Sciences Program, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

3. Division of Nephrology and Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.

4. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

5. Krembil Research Institute, University Health Network and Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

6. Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

7. Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.

8. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Abstract

ABT-263 blocks BCL-X L to induce apoptosis in human dermal fibroblasts from patients with scleroderma and in myofibroblasts in mice, reversing dermal fibrosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference63 articles.

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4. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

5. Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

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