The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation-Reference-Cited by-同舟云学术

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation

Published:2017-05-24 Issue:391 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kodack David P.¹^ORCID,Askoxylakis Vasileios¹^ORCID,Ferraro Gino B.¹,Sheng Qing²^ORCID,Badeaux Mark¹,Goel Shom¹,Qi Xiaolong¹,Shankaraiah Ram¹^ORCID,Cao Z. Alexander²,Ramjiawan Rakesh R.¹^ORCID,Bezwada Divya¹,Patel Bhushankumar¹,Song Yongchul³^ORCID,Costa Carlotta³,Naxerova Kamila¹^ORCID,Wong Christina S. F.¹^ORCID,Kloepper Jonas¹^ORCID,Das Rita²^ORCID,Tam Angela²^ORCID,Tanboon Jantima⁴^ORCID,Duda Dan G.¹^ORCID,Miller C. Ryan⁵^ORCID,Siegel Marni B.⁶^ORCID,Anders Carey K.⁷,Sanders Melinda⁸^ORCID,Estrada Monica V.⁹^ORCID,Schlegel Robert²,Arteaga Carlos L.¹⁰,Brachtel Elena⁴,Huang Alan²^ORCID,Fukumura Dai¹^ORCID,Engelman Jeffrey A.³,Jain Rakesh K.¹^ORCID

Affiliation:

1. Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), Boston, MA 02114, USA.

2. Oncology Translational Medicine, Novartis Institute for Biomedical Research, Cambridge, MA 02139, USA.

3. Department of Medicine, MGH Cancer Center and HMS, Boston, MA 02129, USA.

4. Department of Pathology, MGH and HMS, Boston, MA 02114, USA.

5. Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27514, USA.

6. Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA.

7. Division of Hematology Oncology, Department of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.

8. Department of Pathology, Microbiology, and Immunology, Vanderbilt-Ingram Cancer Center, Nashville, TN 37203, USA.

9. Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Nashville, TN 37203, USA.

10. Departments of Medicine and Cancer Biology, Vanderbilt-Ingram Cancer Center, Nashville, TN 37203, USA.

Abstract

The brain microenvironment triggers HER3-dependent de novo resistance to therapies targeting PI3K or HER2 in HER2-positive and/or PIK3CA -mutant breast cancer cells.

Funder

Susan G. Komen for the Cure

US Department of Defense Breast Cancer Research Innovator Award

US National Cancer Institute Grants

Breast SPORE

NIH/National Cancer Institute

US National Cancer Institute

Ludwig Center at Harvard

MIT-HCC Bridge Grant

Federal Share Proton Beam Program Income

German Research Foundation

Dutch Cancer Society Grant Trustees