High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds-Reference-Cited by-同舟云学术

High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds

Published:2018-02-21 Issue:429 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zampieri Mattia¹^ORCID,Szappanos Balazs¹²^ORCID,Buchieri Maria Virginia³^ORCID,Trauner Andrej⁴⁵^ORCID,Piazza Ilaria⁶,Picotti Paola⁶^ORCID,Gagneux Sébastien⁴⁵^ORCID,Borrell Sonia⁴⁵,Gicquel Brigitte³,Lelievre Joel⁷^ORCID,Papp Balazs²^ORCID,Sauer Uwe¹^ORCID

Affiliation:

1. Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

2. Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.

3. Mycobacterial Genetics Unit, Institut Pasteur, 25-28 Rue du Docteur Roux, 75015 Paris, France.

4. Swiss Tropical and Public Health Institute, Basel, Switzerland.

5. University of Basel, Basel, Switzerland.

6. Institute of Biochemistry, Department of Biology, ETH Zürich, Zürich, Switzerland.

7. Disease of the Developing World, GlaxoSmithKline, Severo Ochoa, Tres Cantos, Madrid 28760, Spain.

Abstract

The mode of action of new antimicrobial compounds can be predicted from changes in metabolome profiles in Mycobacterium .

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference86 articles.

1. Target identification and mechanism of action in chemical biology and drug discovery

2. Target Identification in Chemical Genetics

3. Phenotypic screens as a renewed approach for drug discovery

4. Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

5. A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

Cited by 105 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Utilizing metabolomic approach to study the mode of action of fungicides and corresponding resistance in plant pathogens;Advanced Agrochem;2024-09

2. Persistent glucose consumption under antibiotic treatment protects bacterial community;Nature Chemical Biology;2024-08-13

3. Spectroscopic techniques for elucidating the mechanism of action of antibacterial agents;Applied Spectroscopy Reviews;2024-03-24

4. The metabolic domestication syndrome of budding yeast;Proceedings of the National Academy of Sciences;2024-03-08

5. Machine Learning-Based Metabolic Pattern Recognition Predicts Mode of Action for Anti-Cancer Drug Candidates;2024-01-26