Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing

Author:

Hoyle Nathaniel P.1ORCID,Seinkmane Estere1ORCID,Putker Marrit1ORCID,Feeney Kevin A.1ORCID,Krogager Toke P.1ORCID,Chesham Johanna E.1ORCID,Bray Liam K.1ORCID,Thomas Justyn M.2,Dunn Ken3,Blaikley John4ORCID,O’Neill John S.1ORCID

Affiliation:

1. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

2. Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QH, UK.

3. University Hospital South Manchester and Honorary, Centre for Health Informatics, Institute of Population Health, University of Manchester, Manchester M23 9LT, UK.

4. Centre for Respiratory Medicine and Allergy, University of Manchester and University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT, UK.

Abstract

The circadian clock in fibroblasts determines the efficiency of wound healing through rhythmic regulation of actin cytoskeletal dynamics.

Funder

Wellcome Trust

Medical Research Council

KWF Kankerbestrijding

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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