1. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
2. Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QH, UK.
3. University Hospital South Manchester and Honorary, Centre for Health Informatics, Institute of Population Health, University of Manchester, Manchester M23 9LT, UK.
4. Centre for Respiratory Medicine and Allergy, University of Manchester and University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT, UK.