In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs

Author:

Bez Maxim12ORCID,Sheyn Dmitriy23,Tawackoli Wafa2345ORCID,Avalos Pablo3ORCID,Shapiro Galina1,Giaconi Joseph C.6ORCID,Da Xiaoyu4ORCID,David Shiran Ben23ORCID,Gavrity Jayne7,Awad Hani A.7ORCID,Bae Hyun W.2ORCID,Ley Eric J.2ORCID,Kremen Thomas J.28,Gazit Zulma1238,Ferrara Katherine W.9ORCID,Pelled Gadi12345,Gazit Dan12345ORCID

Affiliation:

1. Skeletal Biotech Laboratory, Hadassah Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem 91120, Israel.

2. Department of Surgery, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.

3. Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

4. Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

5. Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

6. Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

7. Department of Biomedical Engineering and the Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA.

8. Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

9. Department of Biomedical Engineering, University of California, Davis, 451 Health Sciences Drive, Davis, CA 95616, USA.

Abstract

Microbubble-enhanced, ultrasound-mediated BMP-6 gene delivery to endogenous progenitor cells induces rapid and efficient repair of critical-sized, nonunion bone fractures in mini-pigs.

Funder

National Institutes of Health

California Institute for Regenerative Medicine

Israeli Defence Forces Medical Corps

Milgrom Family

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference63 articles.

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