A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants-Reference-Cited by-同舟云学术

A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants

Published:2017-05-03 Issue:388 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhu Qing¹^ORCID,McLellan Jason S.²^ORCID,Kallewaard Nicole L.¹^ORCID,Ulbrandt Nancy D.¹^ORCID,Palaszynski Susan¹,Zhang Jing¹,Moldt Brian¹,Khan Anis³,Svabek Catherine¹^ORCID,McAuliffe Josephine M.¹^ORCID,Wrapp Daniel²,Patel Nita K.¹^ORCID,Cook Kimberly E.⁴,Richter Bettina W. M.¹,Ryan Patricia C.⁵,Yuan Andy Q.⁴^ORCID,Suzich JoAnn A.¹^ORCID

Affiliation:

1. Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

2. Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, 7200 Vail Building, Hanover, NH 03755, USA.

3. Department of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

4. Department of Antibody Discovery and Protein Engineering, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

5. Biologics Safety Assessment, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

Abstract

Development of a highly potent anti-RSV monoclonal antibody with extended half-life intended to be used as RSV prophylaxis for all infants.

Funder

MedImmune, LLC, a wholly owned subsidiary of AstraZeneca Pharmaceutics

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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4. Increasing Burden and Risk Factors for Bronchiolitis-Related Medical Visits in Infants Enrolled in a State Health Care Insurance Plan

5. Outpatient RSV lower respiratory infections among high-risk infants and other pediatric populations

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