Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer-Reference-Cited by-同舟云学术

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Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer

Published:2019-06-26 Issue:498 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhao Ning¹²^ORCID,Peacock Stephanie O.²^ORCID,Lo Chen Hao³^ORCID,Heidman Laine M.¹^ORCID,Rice Meghan A.²^ORCID,Fahrenholtz Cale D.¹^ORCID,Greene Ann M.¹,Magani Fiorella²,Copello Valeria A.²^ORCID,Martinez Maria Julia¹²^ORCID,Zhang Yushan⁴^ORCID,Daaka Yehia⁴^ORCID,Lynch Conor C.³,Burnstein Kerry L.¹²^ORCID

Affiliation:

1. Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

2. Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

3. Department of Tumor Biology, Moffitt Cancer Center, Tampa, FL 33612, USA.

4. Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

Abstract

Antagonism of arginine vasopressin receptor 1a inhibits growth of emergent, established, and bone metastatic castration-resistant prostate cancer.

Funder

U.S. Department of Defense

Wallace H. Coulter Foundation

VA Merit Review

Sylvester Comprehensive Cancer Center Developmental Funds

Florida Academic Cancer Center Alliance

Urology Care Foundation Research Scholar Award

NIH pre-doctoral fellowships

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference57 articles.

1. Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer

2. The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis

3. Vav3, a Rho GTPase Guanine Nucleotide Exchange Factor, Increases during Progression to Androgen Independence in Prostate Cancer Cells and Potentiates Androgen Receptor Transcriptional Activity

4. Ligand-Independent Activation of Androgen Receptors by Rho GTPase Signaling in Prostate Cancer

5. A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer

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