Regulatory T cells engineered with TCR signaling–responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter-Reference-Cited by-同舟云学术

Regulatory T cells engineered with TCR signaling–responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter

Published:2020-11-11 Issue:569 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Eskandari Siawosh K.¹²^ORCID,Sulkaj Ina¹³⁴^ORCID,Melo Mariane B.³⁴^ORCID,Li Na³,Allos Hazim¹^ORCID,Alhaddad Juliano B.¹^ORCID,Kollar Branislav⁵^ORCID,Borges Thiago J.¹⁶^ORCID,Eskandari Arach S.⁷,Zinter Max A.⁸,Cai Songjie¹^ORCID,Assaker Jean Pierre¹^ORCID,Choi John Y.¹^ORCID,Al Dulaijan Basmah S.¹^ORCID,Mansouri Amr¹^ORCID,Haik Yousef¹^ORCID,Tannous Bakhos A.⁸^ORCID,van Son Willem J.²,Leuvenink Henri G. D.⁹^ORCID,Pomahac Bohdan⁵,Riella Leonardo V.¹⁶,Tang Li¹⁰¹¹^ORCID,Seelen Marc A. J.²,Irvine Darrell J.³⁴¹²¹³^ORCID,Azzi Jamil R.¹^ORCID

Affiliation:

1. Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Division of Nephrology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, Netherlands.

3. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

4. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

5. Division of Plastic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

6. Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

7. Department of Electrical Engineering, Delft University of Technology, 2628 CD Delft, Netherlands.

8. Experimental Therapeutics and Molecular Imaging Unit, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

9. Department of Surgery, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, Netherlands.

10. Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

11. Institute of Materials Science and Engineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

12. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

13. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Abstract

Redox-sensitive cytokine cargoes backpacked on regulatory T cells promote local immune regulation in areas of rejection.

Funder

National Institutes of Health

American Diabetes Association

American Heart Association

Qatar Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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