Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

Author:

Ng Benjamin12ORCID,Dong Jinrui2ORCID,D’Agostino Giuseppe2ORCID,Viswanathan Sivakumar2,Widjaja Anissa A.2ORCID,Lim Wei-Wen12ORCID,Ko Nicole S. J.2,Tan Jessie12,Chothani Sonia P.2,Huang Benjamin2ORCID,Xie Chen1,Pua Chee Jian1,Chacko Ann-Marie2ORCID,Guimarães-Camboa Nuno345,Evans Sylvia M.567,Byrne Adam J.8ORCID,Maher Toby M.89ORCID,Liang Jiurong1011ORCID,Jiang Dianhua1011ORCID,Noble Paul W.1011,Schafer Sebastian12ORCID,Cook Stuart A.121213ORCID

Affiliation:

1. National Heart Centre Singapore, 169609 Singapore, Singapore.

2. Duke–National University of Singapore Medical School, 169857 Singapore, Singapore.

3. Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt 60590, Germany.

4. German Center for Cardiovascular Research DZHK, Berlin 10785, Germany.

5. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

6. Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

7. Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.

8. Fibrosis Research Group, Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College, London SW7 2AZ, UK.

9. NIHR Biomedical Research Unit, Royal Brompton Hospital, London SW7 2AZ, UK.

10. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

11. Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

12. National Heart and Lung Institute, Imperial College, London SW3 6LY, UK.

13. MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London W12 0NN, UK.

Abstract

Interleukin-11 is important for lung fibroblast activation in idiopathic pulmonary fibrosis, and its signaling represents a therapeutic target.

Funder

National Medical Research Council (NMRC) Singapore

NIHR Clinician Scientist Fellowship

British Lung Foundation Chair in Respiratory Research

the National Medical Research Council (NMRC) Singapore STaR awards

National Medical Research Council (NMRC) Singapore STaR awards

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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