Intestinal goblet cells protect against GVHD after allogeneic stem cell transplantation via Lypd8-Reference-Cited by-同舟云学术

Intestinal goblet cells protect against GVHD after allogeneic stem cell transplantation via Lypd8

Published:2020-07 Issue:550 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ara Takahide¹^ORCID,Hashimoto Daigo¹^ORCID,Hayase Eiko¹,Noizat Clara¹,Kikuchi Ryo¹,Hasegawa Yuta¹^ORCID,Matsuda Kana²,Ono Shoko²^ORCID,Matsuno Yoshihiro³^ORCID,Ebata Ko¹,Ogasawara Reiki¹^ORCID,Takahashi Shuichiro¹^ORCID,Ohigashi Hiroyuki¹,Yokoyama Emi¹,Matsuo Keitaro⁴⁵,Sugita Junichi¹^ORCID,Onozawa Masahiro¹^ORCID,Okumura Ryu⁶^ORCID,Takeda Kiyoshi⁶,Teshima Takanori¹^ORCID

Affiliation:

1. Department of Hematology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo 060-8638, Japan.

2. Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.

3. Department of Surgical Pathology, Hokkaido University Hospital, Sapporo 060-8648, Japan.

4. Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.

5. Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

6. Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan.

Abstract

Goblet cells play a protective role against GVHD after allogeneic stem cell transplantation in a Lypd8-dependent manner.

Funder

Japan Society for the Promotion of Science

Mochida Memorial Foundation for Medical and Pharmaceutical Research

Center of Innovation Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

1. Graft-versus-host disease