The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation

Author:

Abrahams Melissa-Rose1ORCID,Joseph Sarah B.23ORCID,Garrett Nigel4ORCID,Tyers Lynn1ORCID,Moeser Matthew3ORCID,Archin Nancie5,Council Olivia D.2,Matten David1ORCID,Zhou Shuntai3ORCID,Doolabh Deelan1,Anthony Colin1ORCID,Goonetilleke Nilu25,Karim Salim Abdool46ORCID,Margolis David M.25ORCID,Pond Sergei Kosakovsky7,Williamson Carolyn18ORCID,Swanstrom Ronald39ORCID

Affiliation:

1. Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.

2. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

3. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

4. Centre for the AIDS Programme of Research in South Africa, University of KwaZulu- Natal, Durban 4013, South Africa.

5. UNC HIV Cure Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

6. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.

7. Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.

8. National Health Laboratory Services of South Africa, University of Cape Town, Cape Town 7925, South Africa.

9. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

Outgrowth virus phylogeny suggests that most of the long-lived, replication-competent HIV-1 reservoir is formed near the time of therapy initiation.

Funder

NIH/MRC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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