Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species

Author:

Binderup Tina12ORCID,Duivenvoorden Raphaël13ORCID,Fay Francois14ORCID,van Leent Mandy M. T.1,Malkus Joost1ORCID,Baxter Samantha1ORCID,Ishino Seigo1ORCID,Zhao Yiming1ORCID,Sanchez-Gaytan Brenda1ORCID,Teunissen Abraham J. P.1ORCID,Frederico Yohana C. A.1ORCID,Tang Jun15ORCID,Carlucci Giuseppe56,Lyashchenko Serge57,Calcagno Claudia1,Karakatsanis Nicolas1ORCID,Soultanidis Georgios1ORCID,Senders Max L.18,Robson Philip M.1,Mani Venkatesh1ORCID,Ramachandran Sarayu1ORCID,Lobatto Mark E.19ORCID,Hutten Barbara A.10,Granada Juan F.11ORCID,Reiner Thomas57,Swirski Filip K.12,Nahrendorf Matthias12,Kjaer Andreas2ORCID,Fisher Edward A.13,Fayad Zahi A.1ORCID,Pérez-Medina Carlos114ORCID,Mulder Willem J. M.181516ORCID

Affiliation:

1. Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

2. Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Department of Biomedical Sciences, Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark.

3. Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 XZ Nijmegen, Netherlands.

4. Institut Galien Paris Sud, Faculté de Pharmacie, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 92290 Châtenay-Malabry, France.

5. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

6. Bernard and Irene Schwarz Center for Biomedical Imaging, New York University, New York, NY 10016, USA.

7. Department of Radiology, Weill Cornell Medical College, New York, NY 10065, USA.

8. Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.

9. Department of Radiology, Spaarne Gasthuis, 2035 RC Haarlem, Netherlands.

10. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centers, 1105 AZ Amsterdam, Netherlands.

11. CRF Skirball Center for Innovation, Cardiovascular Research Foundation, Orangeburg, NY 10962, USA.

12. Center for Systems Biology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

13. Department of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, NY 10016, USA.

14. Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain.

15. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

16. Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612 AZ Eindhoven, Netherlands.

Abstract

A nanoimmunotherapy reduces inflammation in mouse, rabbit, and pig models of atherosclerosis.

Funder

National Institutes of Health

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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