Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis-Reference-Cited by-同舟云学术

Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis

Published:2019-11-20 Issue:519 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Mensah Kofi A.¹²^ORCID,Chen Jeff W.²^ORCID,Schickel Jean-Nicolas²,Isnardi Isabelle³,Yamakawa Natsuko²^ORCID,Vega-Loza Andrea²,Anolik Jennifer H.⁴,Gatti Richard A.⁵,Gelfand Erwin W.⁶,Montgomery Ruth R.¹^ORCID,Horowitz Mark C.⁷,Craft Joe E.¹²^ORCID,Meffre Eric¹²^ORCID

Affiliation:

1. Section of Rheumatology, Allergy, and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06511, USA.

2. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA.

3. Novartis Institute for Biomedical Research, Basel, Switzerland.

4. Division of Rheumatology, Allergy, and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

5. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

6. Department of Pediatrics, National Jewish Health, University of Colorado, Denver, CO 80113, USA.

7. Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06511, USA.

Abstract

Defective ATM activation skews the B cell repertoire and increases RANKL production, promoting joint erosion in patients with rheumatoid arthritis.

Funder

National Institutes of Health

Robert E. Leet and Clara Guthrie Patterson Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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4. Impaired early B cell tolerance in patients with rheumatoid arthritis

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