Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

Author:

Hutson Thomas H.1ORCID,Kathe Claudia23ORCID,Palmisano Ilaria1,Bartholdi Kay3,Hervera Arnau1ORCID,De Virgiliis Francesco1ORCID,McLachlan Eilidh1,Zhou Luming14,Kong Guiping14,Barraud Quentin3ORCID,Danzi Matt C.5ORCID,Medrano-Fernandez Alejandro6,Lopez-Atalaya Jose P.6ORCID,Boutillier Anne L.7ORCID,Sinha Sarmistha H.8ORCID,Singh Akash K.8ORCID,Chaturbedy Piyush9,Moon Lawrence D. F.2ORCID,Kundu Tapas K.8ORCID,Bixby John L.5ORCID,Lemmon Vance P.5ORCID,Barco Angel6ORCID,Courtine Gregoire3ORCID,Di Giovanni Simone14ORCID

Affiliation:

1. Centre for Restorative Neuroscience, Division of Brain Sciences, Department of Medicine, Imperial College London, London W12 0NN, UK.

2. Neurorestoration Group, Wolfson Centre for Age-Related Diseases, King’s College London, London SE1 1UL, UK.

3. Brain Mind Institute and Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1202 Geneva, Switzerland.

4. Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany.

5. Miami Project to Cure Paralysis, University of Miami, Miami, FL 33136, USA.

6. Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Científicas, 03550 Alicante, Spain.

7. Université de Strasbourg, CNRS, UMR 7364, Laboratoire de Neuroscience Cognitives et Adaptatives (LNCA), F-67000 Strasbourg, France.

8. Transcription and Disease Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.

9. Nanomaterials and Catalysis Laboratory, Chemistry and Physics of Materials Unit, JNCASR, Bangalore 560064, India.

Abstract

Environmental enrichment induces activity-dependent histone acetylation via a druggable mechanism to promote recovery after spinal cord injury.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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