Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells

Author:

Peired Anna Julie12ORCID,Antonelli Giulia12,Angelotti Maria Lucia12,Allinovi Marco123ORCID,Guzzi Francesco2ORCID,Sisti Alessandro4ORCID,Semeraro Roberto2,Conte Carolina12,Mazzinghi Benedetta4,Nardi Sara4,Melica Maria Elena12ORCID,De Chiara Letizia4ORCID,Lazzeri Elena12,Lasagni Laura12,Lottini Tiziano5,Landini Samuela2ORCID,Giglio Sabrina2,Mari Andrea6ORCID,Di Maida Fabrizio6ORCID,Antonelli Alessandro7ORCID,Porpiglia Francesco8,Schiavina Riccardo9,Ficarra Vincenzo10,Facchiano Davide6,Gacci Mauro6,Serni Sergio6,Carini Marco6,Netto George J.11,Roperto Rosa Maria4ORCID,Magi Alberto2,Christiansen Christian Fynbo12ORCID,Rotondi Mario13,Liapis Helen14ORCID,Anders Hans-Joachim15ORCID,Minervini Andrea6,Raspollini Maria Rosaria16ORCID,Romagnani Paola124ORCID

Affiliation:

1. Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), University of Florence, Florence 50139, Italy.

2. Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University of Florence, Florence 50139, Italy.

3. Nephrology, Dialysis and Transplantation Unit, Careggi University Hospital, Florence 50139, Italy.

4. Nephrology and Dialysis Unit, Meyer Children’s University Hospital, Florence 50139, Italy.

5. Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence 50139, Italy.

6. Department of Urology, Careggi Hospital, University of Florence, Florence 50139, Italy.

7. Department of Urology, Spedali Civili Hospital, University of Brescia, Brescia 25123, Italy.

8. Department of Urology, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin 10043, Italy.

9. Department of Urology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna 40138, Italy.

10. Department of Urology, University of Padua, Padua 35122, Italy.

11. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

12. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus 8200, Denmark.

13. Unit of Internal Medicine and Endocrinology, ICS Maugeri I.R.C.C.S., Scientific Institute of Pavia, Pavia 28100, Italy.

14. Arkana Laboratories, Little Rock, AR 72211, USA.

15. Division of Nephrology, Medizinische Klinik and Poliklinik IV, Klinikum der LMU München, Munich 80336, Germany.

16. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence 50139, Italy.

Abstract

Papillary renal cell carcinoma derives from renal progenitors in an adenoma-carcinoma sequence, and acute kidney injury is a preventable risk factor.

Funder

H2020 European Research Council

Fondazione Umberto Veronesi

Associazione Italiana per la Ricerca sul Cancro

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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