Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma-Reference-Cited by-同舟云学术

Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma

Published:2020-03-04 Issue:533 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wang Dongrui¹²^ORCID,Starr Renate¹^ORCID,Chang Wen-Chung¹^ORCID,Aguilar Brenda¹,Alizadeh Darya¹,Wright Sarah L.¹^ORCID,Yang Xin¹^ORCID,Brito Alfonso¹,Sarkissian Aniee¹,Ostberg Julie R.¹,Li Li²³,Shi Yanhong³,Gutova Margarita³,Aboody Karen³^ORCID,Badie Behnam⁴,Forman Stephen J.¹,Barish Michael E.³^ORCID,Brown Christine E.¹⁵^ORCID

Affiliation:

1. Department of Hematology & Hematopoietic Cell Transplantation, City of Hope Medical Center, Duarte, CA 91010, USA.

2. Irell and Manella Graduate School of Biological Sciences, City of Hope Beckman Research Institute, Duarte, CA 91010, USA.

3. Department of Developmental and Stem Cell Biology, City of Hope Beckman Research Institute, Duarte, CA 91010, USA.

4. Division of Neurosurgery, Department of Surgery, City of Hope Medical Center, Duarte, CA 91010, USA.

5. Department of Immuno-Oncology, City of Hope Beckman Research Institute, Duarte, CA 91010, USA.

Abstract

CAR T cells using chlorotoxin as the tumor-targeting domain recognize and kill glioblastoma with high specificity and potency.

Funder

National Cancer Institute

Ben and Catherine Ivy Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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