A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies-Reference-Cited by-同舟云学术

A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies

Published:2020-01-08 Issue:525 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Skokos Dimitris¹^ORCID,Waite Janelle C.¹^ORCID,Haber Lauric¹^ORCID,Crawford Alison¹^ORCID,Hermann Aynur¹^ORCID,Ullman Erica¹^ORCID,Slim Rabih¹,Godin Stephen¹,Ajithdoss Dharani¹,Ye Xuan¹^ORCID,Wang Bei¹^ORCID,Wu Qi¹^ORCID,Ramos Ilyssa¹,Pawashe Arpita¹^ORCID,Canova Lauren¹,Vazzana Kristin¹,Ram Priyanka¹,Herlihy Evan¹^ORCID,Ahmed Hassan¹^ORCID,Oswald Erin¹,Golubov Jacquelynn¹^ORCID,Poon Patrick¹^ORCID,Havel Lauren¹,Chiu Danica¹^ORCID,Lazo Miguel¹^ORCID,Provoncha Kathleen¹^ORCID,Yu Kevin¹^ORCID,Kim Julie¹,Warsaw Jacqueline J.¹,Stokes Oristian Nicole¹^ORCID,Siao Chia-Jen¹^ORCID,Dudgeon Drew¹^ORCID,Huang Tammy¹,Potocky Terra¹,Martin Joel¹^ORCID,MacDonald Douglas¹^ORCID,Oyejide Adelekan¹,Rafique Ashique¹^ORCID,Poueymirou William¹^ORCID,Kirshner Jessica R.¹^ORCID,Smith Eric¹,Olson William¹^ORCID,Lin John¹,Thurston Gavin¹,Sleeman Matthew A.¹^ORCID,Murphy Andrew J.¹^ORCID,Yancopoulos George D.¹

Affiliation:

1. Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.

Abstract

CD28 bispecific antibodies are well tolerated and enhance the antitumor efficacy of CD3 bispecifics as a potential off-the-shelf antibody therapy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference50 articles.

1. T-cell-antigen recognition and the immunological synapse

2. CD28 Costimulation: From Mechanism to Therapy

3. F-Actin-Driven CD28-CD80 Localization in the Immune Synapse