Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors-Reference-Cited by-同舟云学术

Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors

Published:2020-03-11 Issue:534 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Schafer Johanna M.¹^ORCID,Lehmann Brian D.²³^ORCID,Gonzalez-Ericsson Paula I.³^ORCID,Marshall Clayton B.¹³^ORCID,Beeler J. Scott¹^ORCID,Redman Lindsay N.¹^ORCID,Jin Hailing³^ORCID,Sanchez Violeta³^ORCID,Stubbs Matthew C.⁴^ORCID,Scherle Peggy⁵^ORCID,Johnson Kimberly N.³,Sheng Quanhu⁶^ORCID,Roland Joseph T.⁷^ORCID,Bauer Joshua A.¹⁸^ORCID,Shyr Yu⁶^ORCID,Chakravarthy Bapsi³⁹^ORCID,Mobley Bret C.¹⁰^ORCID,Hiebert Scott W.¹³,Balko Justin M.²³^ORCID,Sanders Melinda E.³¹⁰,Liu Phillip C. C.¹¹,Pietenpol Jennifer A.¹³^ORCID

Affiliation:

1. Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

2. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

3. Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

4. Incyte Corporation, Wilmington, DE 19803, USA.

5. Prelude Therapeutics, Wilmington, DE 19803, USA.

6. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

7. Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

8. Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA.

9. Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

10. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

11. Kymera Therapeutics, Cambridge, MA 02139, USA.

Abstract

This study demonstrates the potential utility of BET and MEK inhibitors for advanced MYCN-expressing triple-negative breast cancer.

Funder

National Cancer Institute

Susan G. Komen for the Cure

Incyte Corporation

Susan G. Komen

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference79 articles.

1. Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study

2. Triple-Negative Breast Cancer: Clinical Features and Patterns of Recurrence

3. The clonal and mutational evolution spectrum of primary triple-negative breast cancers

4. Comprehensive molecular portraits of human breast tumours

5. The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

Cited by 48 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

2. Epigenetic modulations in triple-negative breast cancer: Therapeutic implications for tumor microenvironment;Pharmacological Research;2024-06

3. Chemotherapy-elicited extracellular vesicle CXCL1 from dying cells promotes triple-negative breast cancer metastasis by activating TAM/PD-L1 signaling;Journal of Experimental & Clinical Cancer Research;2024-04-23

4. MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma;Cell Death & Disease;2024-02-09

5. Natural polyphenol-loaded cross-linked lipoic acid vesicles treat triple-negative breast cancer by cancer cell killing and metastasis inhibition;Materials & Design;2023-12