Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment

Author:

Liu Honghai1ORCID,Zhang Cheng-Hai23ORCID,Ammanamanchi Niyatie1ORCID,Suresh Sangita23ORCID,Lewarchik Christopher1,Rao Krithika1,Uys Gerrida M.23ORCID,Han Lu1ORCID,Abrial Maryline23ORCID,Yimlamai Dean4,Ganapathy Balakrishnan1,Guillermier Christelle5,Chen Nathalie1ORCID,Khaladkar Mugdha6ORCID,Spaethling Jennifer7,Eberwine James H.7ORCID,Kim Junhyong6ORCID,Walsh Stuart23,Choudhury Sangita23,Little Kathryn1,Francis Kimberly1,Sharma Mahesh8,Viegas Melita9ORCID,Bais Abha10ORCID,Kostka Dennis101112ORCID,Ding Jun13,Bar-Joseph Ziv13ORCID,Wu Yijen1014ORCID,Yechoor Vijay15ORCID,Moulik Mousumi16,Johnson Jennifer1617,Weinberg Jacqueline16ORCID,Reyes-Múgica Miguel18ORCID,Steinhauser Matthew L.5,Kühn Bernhard11920ORCID

Affiliation:

1. Richard King Mellon Foundation Institute for Pediatric Research and Division of Cardiology, UPMC Children’s Hospital of Pittsburgh and Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA.

2. Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, USA.

3. Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

4. Department of Pediatric Gastroenterology, Hepatology and Nutrition, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

5. Division of Genetics and Harvard Medical School, Brigham and Women’s Hospital, Boston, MA 02115, USA.

6. Department of Biology, School of Arts and Sciences, University of Pennsylvania, 301A/B Lynch Laboratory, 433 S University Avenue, Philadelphia, PA 19104, USA.

7. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

8. Division of Cardiothoracic Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

9. Pediatric Cardiothoracic Surgery, UPMC Children’s Hospital of Pittsburgh and Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA 15224, USA.

10. Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA.

11. Department of Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

12. Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

13. Computational Biology Department and Machine Learning Department, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

14. Rangos Research Center Animal Imaging Core, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

15. Diabetes and Beta Cell Biology Center, Division of Endocrinology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15238, USA.

16. Division of Cardiology, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.

17. Neonatal-Perinatal Medicine, UPMC Magee-Womens Hospital, Pittsburgh, PA 15213, USA.

18. Division of Pediatric Pathology, UPMC Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.

19. McGowan Institute of Regenerative Medicine, Pittsburgh, PA 15219, USA.

20. Pediatric Institute for Heart Regeneration and Therapeutics, Pittsburgh, PA 15224, USA.

Abstract

Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating the established number of cardiomyocytes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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