Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance-Reference-Cited by-同舟云学术

Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance

Published:2020-02-26 Issue:532 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Azzimato Valerio¹^ORCID,Jager Jennifer²^ORCID,Chen Ping¹^ORCID,Morgantini Cecilia¹^ORCID,Levi Laura¹,Barreby Emelie¹^ORCID,Sulen André¹^ORCID,Oses Carolina¹^ORCID,Willerbrords Joost¹,Xu Connie¹^ORCID,Li Xidan¹,Shen Joanne X.³,Akbar Naveed⁴^ORCID,Haag Lars⁵,Ellis Ewa⁶^ORCID,Wålhen Kerstin⁷,Näslund Erik⁸^ORCID,Thorell Anders⁸⁹^ORCID,Choudhury Robin P.⁴^ORCID,Lauschke Volker M.³^ORCID,Rydén Mikael⁷^ORCID,Craige Siobhan M.¹⁰,Aouadi Myriam¹^ORCID

Affiliation:

1. Integrated Cardio Metabolic Center, Department of Medicine, Karolinska Institutet, 141 57 Huddinge, Sweden.

2. Université Côte d’Azur, Inserm U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity, 06000 Nice, France.

3. Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Solna, Sweden.

4. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DU Oxford, UK.

5. Department of Laboratory Medicine, Laboratory Medicine, Karolinska Institutet, 141 57 Huddinge, Sweden.

6. Division of Transplantation Surgery, Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, 141 57 Huddinge, Sweden.

7. Unit of Endocrinology Department of Medicine, Karolinska Institutet, 141 57 Huddinge, Sweden.

8. Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, 182 88 Stockholm, Sweden.

9. Department of Surgery, Ersta Hospital, Karolinska Institutet, 116 28 Stockholm, Sweden.

10. Human Nutrition, Food, and Exercise Department, Virginia Tech, Blacksburg, VA 24060, USA.

Abstract

Liver macrophages exacerbate oxidative stress in obesity-induced hepatic steatosis by blocking the endogenous antioxidant response.

Funder

AstraZeneca

Familjen Erling-Perssons Stiftelse

Stockholms Läns Landsting

Swedish Research Council for Health, Working Life and Welfare

Strategic Research Council

Novo Nordisk Foundation Center for Basic Metabolic Research

Novo Nordisk Fonden

Diabetes Wellness Foundation Sweden

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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5. The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD)

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