Riluzole blocks perioperative ischemia-reperfusion injury and enhances postdecompression outcomes in cervical spondylotic myelopathy-Reference-Cited by-同舟云学术

Riluzole blocks perioperative ischemia-reperfusion injury and enhances postdecompression outcomes in cervical spondylotic myelopathy

Published:2015-12-02 Issue:316 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Karadimas Spyridon K.¹²,Laliberte Alex M.¹²,Tetreault Lindsay¹²,Chung Young Sun²,Arnold Paul³,Foltz Warren D.⁴,Fehlings Michael G.¹²⁵

Affiliation:

1. Institute of Medical Sciences, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

2. Division of Genetics and Development, Toronto Western Research Institute, and Spinal Program, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario M5T 2S8, Canada.

3. Department of Neurosurgery, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

4. Spatio-Temporal Targeting and Amplification of Radiation Response (STTARR) Innovation Centre, Department of Radiation Oncology, University Health Network, Toronto, Ontario M5G 1L7, Canada.

5. Department of Surgery, Division of Neurosurgery and Spinal Program, University of Toronto, Toronto, Ontario M5T 2S8, Canada.

Abstract

Riluzole complements surgical decompression in an animal model of cervical spondylotic myelopathy, improving long-term outcomes.

Funder

Cervical Spine Research Society

Canadian Institutes of Health Research

CIHR

Alexander S. Onassis Public Benefit Foundation

Gerry and Tootsie Halbert Regeneration Chair

Publisher

American Association for the Advancement of Science (AAAS)

Subject