Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction-Reference-Cited by-同舟云学术

Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction

Published:2016-03-16 Issue:330 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wehmeyer Corinna¹,Frank Svetlana¹,Beckmann Denise¹,Böttcher Martin²,Cromme Christoph¹,König Ulrich¹,Fennen Michelle¹,Held Annelena¹,Paruzel Peter¹,Hartmann Christine¹,Stratis Athanasios¹,Korb-Pap Adelheid¹,Kamradt Thomas²,Kramer Ina³,van den Berg Wim⁴,Kneissel Michaela³,Pap Thomas¹,Dankbar Berno¹

Affiliation:

1. Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, 48149 Muenster, Germany.

2. Institute of Immunology, University Hospital Jena, 07743 Jena, Germany.

3. Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.

4. Nijmegen Centre for Molecular Life Sciences, 86525 Nijmegen, Netherlands.

Abstract

Blocking the Wnt inhibitor sclerostin leads to inflammatory joint destruction through enhanced activation of TNF receptor–mediated signaling, implicating sclerostin as protective in TNFα-dependent chronic inflammation.

Funder

German Research Foundation

Collaborative Research Center

DFG

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

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