A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates-Reference-Cited by-同舟云学术

A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

Published:2015-08-19 Issue:301 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Muthumani Karuppiah¹,Falzarano Darryl²,Reuschel Emma L.¹,Tingey Colleen¹,Flingai Seleeke¹,Villarreal Daniel O.¹,Wise Megan¹,Patel Ami¹,Izmirly Abdullah¹,Aljuaid Abdulelah¹,Seliga Alecia M.¹,Soule Geoff³,Morrow Matthew⁴,Kraynyak Kimberly A.⁴,Khan Amir S.⁴,Scott Dana P.⁵,Feldmann Friederike⁵,LaCasse Rachel⁵,Meade-White Kimberly⁵,Okumura Atsushi⁶,Ugen Kenneth E.⁷,Sardesai Niranjan Y.⁴,Kim J. Joseph⁴,Kobinger Gary³,Feldmann Heinz²,Weiner David B.¹

Affiliation:

1. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.

2. Laboratory of Virology, Division of Intramural Research, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA.

3. Special Pathogens Program, University of Manitoba and Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

4. Inovio Pharmaceuticals Inc., Plymouth Meeting, PA 19462, USA.

5. Rocky Mountain Veterinary Branch, Division of Intramural Research, NIAID, NIH, Hamilton, MT 59840, USA.

6. Department of Microbiology, University of Washington, Seattle, WA 98195, USA.

7. Department of Molecular Medicine, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.

Abstract

A consensus MERS spike protein synthetic DNA vaccine can induce protective responses against viral challenge.

Funder

NIH

National Institute of Allergy and Infectious Diseases

Inovio Pharmaceuticals Inc.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference53 articles.

1. Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions

2. MERS-CoV: in search of answers

3. Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study

4. Emergence of the Middle East Respiratory Syndrome Coronavirus

5. Middle East Respiratory Syndrome Coronavirus Infections in Health Care Workers

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