Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase-Reference-Cited by-同舟云学术

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

Published:2016-05-25 Issue:340 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Reilly Svetlana N.¹,Liu Xing¹,Carnicer Ricardo¹,Recalde Alice¹,Muszkiewicz Anna²,Jayaram Raja¹,Carena Maria Cristina¹,Wijesurendra Rohan¹,Stefanini Matilde¹,Surdo Nicoletta C.¹,Lomas Oliver¹,Ratnatunga Chandana³,Sayeed Rana³,Krasopoulos George³,Rajakumar Timothy⁴,Bueno-Orovio Alfonso²,Verheule Sander,Fulga Tudor A.⁴,Rodriguez Blanca²,Schotten Ulrich,Casadei Barbara¹

Affiliation:

1. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

2. Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK.

3. Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.

4. Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.

Abstract

Atrial microRNA-31 up-regulation causes dystrophin and nNOS depletion, which in turn contributes to the electrical phenotype of atrial fibrillation.

Funder

British Heart Foundation (BHF)

Oxford BHF Centre of Excellence

Fondation Leducq Network of Excellence

European Union 7th Framework Programme

Wellcome Trust

Weatherall Institute of Molecular Medicine

UK Medical Research Council

Wellcome Trust Senior Research Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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