Human endogenous retrovirus-K contributes to motor neuron disease

Author:

Li Wenxue1,Lee Myoung-Hwa1,Henderson Lisa1,Tyagi Richa1,Bachani Muzna2,Steiner Joseph2,Campanac Emilie3,Hoffman Dax A.3,von Geldern Gloria1,Johnson Kory4,Maric Dragan1,Morris H. Douglas5,Lentz Margaret6,Pak Katherine7,Mammen Andrew7,Ostrow Lyle8,Rothstein Jeffrey8,Nath Avindra1

Affiliation:

1. Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

2. Neurotherapeutics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

3. Molecular Neurophysiology and Biophysics Section, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

4. Bioinformatics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 21042, USA.

5. Mouse Imaging Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 21042, USA.

6. Integrated Research Facility, National Institute of Allergy and Infectious Disease, National Institutes of Health, Fort Detrick, Frederick, MD 21042, USA.

7. Laboratory of Muscle Stem Cell and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 21042 , USA.

8. Department of Neurology, Johns Hopkins University, Baltimore, MD 28217, USA.

Abstract

Human endogenous retrovirus-K is activated in the cortical neurons of patients with amyotrophic lateral sclerosis, and expression of the viral envelope protein in mouse brain reproduces the clinical and pathological phenotype of this disease.

Funder

National Institute of Arthritis, Musculoskeletal and Skin Diseases

National Institute of Neurological Disorders and Stroke

NICHD of the NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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