Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera-Reference-Cited by-同舟云学术

Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera

Published:2015-10-14 Issue:309 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ngwuta Joan O.¹,Chen Man¹,Modjarrad Kayvon¹²,Joyce M. Gordon¹,Kanekiyo Masaru¹,Kumar Azad¹,Yassine Hadi M.¹,Moin Syed M.¹,Killikelly April M.¹,Chuang Gwo-Yu¹,Druz Aliaksandr¹,Georgiev Ivelin S.¹,Rundlet Emily J.¹,Sastry Mallika¹,Stewart-Jones Guillaume B. E.¹,Yang Yongping¹,Zhang Baoshan¹,Nason Martha C.¹,Capella Cristina³,Peeples Mark E.³,Ledgerwood Julie E.¹,McLellan Jason S.¹⁴,Kwong Peter D.¹,Graham Barney S.¹

Affiliation:

1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

2. U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

3. The Research Institute at Nationwide Children’s Hospital and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205, USA.

4. Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.

Abstract

Antibodies to the prefusion conformation of the RSV F glycoprotein neutralize natural infection.

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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