Aging as a driver of leukemogenesis-Reference-Cited by-同舟云学术

Aging as a driver of leukemogenesis

Published:2015-09-23 Issue:306 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

McKerrell Thomas¹²,Vassiliou George S.¹²³

Affiliation:

1. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

2. Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK.

3. Department of Haematology, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, UK.

Abstract

Certain leukemia-initiating mutations drive expansion of hemopoietic clones specifically under the selection pressures that prevail in an aged microenvironment.

Funder

Wellcome Trust Clinician Scientist Fellowship

Wellcome Trust Senior Fellowship in Clinical Science

Celgene

Kay Kendall Leukaemia Fund

Bloodwise (Leukaemia Lymphoma Research)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference10 articles.

1. Persistence of leukaemic ancestors

3. Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis

4. Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

5. High burden and pervasive positive selection of somatic mutations in normal human skin

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