PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2-Reference-Cited by-同舟云学术

PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2

Published:2015-10-21 Issue:310 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Witney Timothy H.¹,James Michelle L.¹²,Shen Bin¹,Chang Edwin¹,Pohling Christoph¹,Arksey Natasha¹,Hoehne Aileen¹,Shuhendler Adam¹,Park Jun-Hyung¹,Bodapati Deepika¹,Weber Judith¹,Gowrishankar Gayatri¹,Rao Jianghong¹,Chin Frederick T.¹,Gambhir Sanjiv Sam¹³

Affiliation:

1. Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 943065, USA.

2. Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 943065, USA.

3. Departments of Bioengineering and Materials Science & Engineering, Bio-X, Stanford University, Stanford, CA 943065, USA.

Abstract

A PET imaging reagent targeting PKM2 allows noninvasive assessment of glycolysis in glioblastoma multiforme, distinguishing it from normal brain tissue.

Funder

National Cancer Institute (NCI)

NCI

Canary Foundation

Ben and Catherine Ivy Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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