Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle-Reference-Cited by-同舟云学术

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

Published:2015-11-18 Issue:314 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Miller Miles A.¹²,Gadde Suresh³,Pfirschke Christina¹,Engblom Camilla¹,Sprachman Melissa M.¹,Kohler Rainer H.¹²,Yang Katherine S.¹,Laughney Ashley M.¹,Wojtkiewicz Gregory¹,Kamaly Nazila³,Bhonagiri Sushma³,Pittet Mikael J.¹²,Farokhzad Omid C.³⁴,Weissleder Ralph¹²⁵

Affiliation:

1. Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

2. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

3. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

4. King Abdulaziz University, Jeddah, Saudi Arabia.

5. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Magnetic nanoparticles predict the efficacy of drug-loaded polymeric nanoparticles in vivo, helping select for tumors more responsive to nanomedicine.

Funder

NIH

DoD

Deutsche Forschungsgemeinschaft (DFG)

David H. Koch-Prostate Cancer Foundation Award in Nanotherapeutics

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference38 articles.

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2. The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo