Human IFNAR2 deficiency: Lessons for antiviral immunity

Author:

Duncan Christopher J. A.12,Mohamad Siti M. B.13,Young Dan F.4,Skelton Andrew J.5,Leahy T. Ronan6,Munday Diane C.4,Butler Karina M.6,Morfopoulou Sofia7,Brown Julianne R.89,Hubank Mike10,Connell Jeff11,Gavin Patrick J.6,McMahon Cathy12,Dempsey Eugene13,Lynch Niamh E.14,Jacques Thomas S.15,Valappil Manoj16,Cant Andrew J.117,Breuer Judith78,Engelhardt Karin R.1,Randall Richard E.4,Hambleton Sophie117

Affiliation:

1. Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.

2. Department of Infectious Diseases and Tropical Medicine, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.

3. Advanced Medical and Dental Institute, Universiti Sains Malaysia, 11800 Penang, Malaysia.

4. School of Biology, University of St. Andrews, St. Andrews KY16 9ST, UK.

5. Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.

6. Department of Pediatric Infectious Diseases and Immunology, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.

7. Division of Infection and Immunity, University College London, London WC1E 6BT, UK.

8. Virology Department, Great Ormond Street Hospital for Children National Health Service (NHS) Foundation Trust, London WC1N 3JH, UK.

9. National Institutes of Health Research Biomedical Research Centre, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.

10. Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, London WC1E 6BT, UK.

11. National Virus Reference Laboratory, University College Dublin, Belfield, Dublin 4, Ireland.

12. Department of Pediatric Intensive Care and Anaesthetics, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.

13. INFANT Centre, Cork University Maternity Hospital, University College Cork, Ireland.

14. Department of Pediatrics, Bon Secours Hospital, Cork, Ireland.

15. Developmental Biology and Cancer Programme, University College London Institute of Child Health, London WC1N 1EH, UK.

16. Public Health England, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.

17. Pediatric Immunology Service, Great North Children’s Hospital, Newcastle upon Tyne NE1 4LP, UK.

Abstract

Human IFNAR2 deficiency causes fatal susceptibility to live viral vaccines.

Funder

Wellcome Trust

UK NIH Research (NIHR)

Medical Research Council

Sir Jules Thorn Trust

Academy of Medical Sciences

Universiti Sains Malaysia Fellowship

British Infection Association

UCLH/UCL NIHR Biomedical Research Centre

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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