Chimpanzee adenovirus– and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults

Author:

Green Christopher A.1,Scarselli Elisa2,Sande Charles J.1,Thompson Amber J.1,de Lara Catherine M.3,Taylor Kathryn S.1,Haworth Kathryn1,Del Sorbo Mariarosaria2,Angus Brian1,Siani Loredana2,Di Marco Stefania2,Traboni Cinzia2,Folgori Antonella2,Colloca Stefano2,Capone Stefania2,Vitelli Alessandra2,Cortese Riccardo4,Klenerman Paul3,Nicosia Alfredo256,Pollard Andrew J.1

Affiliation:

1. Oxford Vaccine Group, Department of Paediatrics, and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7LE, UK.

2. ReiThera SRL (formerly Okairos SRL), Viale Città d’Europa 679, 00144 Rome, Italy.

3. Experimental Medicine Division, Nuffield Department of Medicine, Peter Medawar Building, University of Oxford, Oxford OX1 3SY, UK.

4. Keires AG, Bäumleingasse 18, 4051 Basel, Switzerland.

5. CEINGE, Via Gaetano Salvatore 486, 80145 Naples, Italy.

6. Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.

Abstract

The RSV vaccine candidates PanAd3-RSV and MVA-RSV were safe and immunogenic in healthy adults.

Funder

Wellcome Trust

ReiThera SRL

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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