Different human resting memory CD4 + T cell subsets show similar low inducibility of latent HIV-1 proviruses-Reference-Cited by-同舟云学术

Different human resting memory CD4 + T cell subsets show similar low inducibility of latent HIV-1 proviruses

Published:2020-01-29 Issue:528 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kwon Kyungyoon J.¹^ORCID,Timmons Andrew E.¹,Sengupta Srona¹^ORCID,Simonetti Francesco R.¹^ORCID,Zhang Hao²,Hoh Rebecca³^ORCID,Deeks Steven G.³^ORCID,Siliciano Janet D.¹^ORCID,Siliciano Robert F.¹⁴^ORCID

Affiliation:

1. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

2. Flow Cytometry and Immunology Core, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

3. Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

4. Howard Hughes Medical Institute, Baltimore, MD, USA.

Abstract

Latent replication-competent HIV-1 proviruses in different memory T cell subsets show no differences in viral gene transcription after T cell activation.

Funder

Howard Hughes Medical Institute

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference94 articles.

1. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

2. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

3. In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency