Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice

Author:

Lai Ke1ORCID,Song Xing-Lei2ORCID,Shi Hao-Song1,Qi Xin2ORCID,Li Chun-Yan1,Fang Jia1,Wang Fan1,Maximyuk Oleksandr3ORCID,Krishtal Oleg3ORCID,Xu Tian-Le2ORCID,Li Xiao-Yan4,Ni Kun4,Li Wan-Peng4,Shi Hai-Bo1ORCID,Wang Lu-Yang56ORCID,Yin Shan-Kai1

Affiliation:

1. Department of Otorhinolaryngology, Sixth People’s Hospital of Shanghai and Shanghai Jiao Tong University, Shanghai 200032, China.

2. Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

3. Bogomoletz Institute of Physiology of NAS Ukraine, Kyiv 01024, Ukraine.

4. Department of Otorhinolaryngology, Shanghai Children Hospital and Shanghai Jiao Tong University, Shanghai 200062, China.

5. Program in Neuroscience and Mental Health, SickKids Research Institute, Toronto M5G 1X8, Canada.

6. Department of Physiology, University of Toronto, Toronto M5S 1A1, Canada.

Abstract

Neonatal hyperbilirubinemia aggravates acidosis-dependent long-term brain injury.

Funder

Canadian Institutes of Health Research

National Natural Science Foundation of China

Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support

Shanghai Outstanding Academic Leaders Plan

The Science and Technology Commission of Shanghai Municipality and the Innovative Research Team of High-level Local Universities in Shanghai

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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