Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer

Author:

Luo Huiyan1ORCID,Zhao Qi1ORCID,Wei Wei1ORCID,Zheng Lianghong2ORCID,Yi Shaohua3ORCID,Li Gen4,Wang Wenqiu5,Sheng Hui1,Pu Hengying1,Mo Haiyu1,Zuo Zhixiang1ORCID,Liu Zexian1ORCID,Li Chaofeng1,Xie Chuanbo1,Zeng Zhaolei1ORCID,Li Weimin6ORCID,Hao Xiaoke7,Liu Yuying1,Cao Sumei1,Liu Wanli1,Gibson Sarah4ORCID,Zhang Kang68,Xu Guoliang1,Xu Rui-hua1ORCID

Affiliation:

1. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P. R. China.

2. Guangzhou Youze Biological Pharmaceutical Technology Company Ltd., Guangzhou 510005, P.R. China.

3. Huazhong University of Science and Technology Tongji Medical College, Wuhan 430030, P. R. China.

4. Guangzhou Women and Children’s Medical Center, Guangzhou 510623, P. R. China.

5. Shanghai General Hospital, Shanghai 200080, P. R. China.

6. Molecular Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.

7. Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.

8. Faculty of Medicine, Macau University of Science and Technology, Macau 999078, P. R. China.

Abstract

Circulating tumor DNA methylation–based signatures are potential biomarkers for early diagnosis and prognosis of colorectal cancer.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Natural Science Foundation of Guangdong Province

National key R&D program of China

Science and Technology Program of Guangzhou

Science and Technology Program of Guangdong

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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