Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa

Author:

Gray Glenda E.123ORCID,Huang Ying3ORCID,Grunenberg Nicole3ORCID,Laher Fatima1ORCID,Roux Surita4ORCID,Andersen-Nissen Erica35,De Rosa Stephen C.3,Flach Britta5,Randhawa April K.3ORCID,Jensen Ryan3ORCID,Swann Edith M.6ORCID,Bekker Linda-Gail4,Innes Craig7,Lazarus Erica1ORCID,Morris Lynn8ORCID,Mkhize Nonhlanhla N.8ORCID,Ferrari Guido9,Montefiori David C.9ORCID,Shen Xiaoying9,Sawant Sheetal9ORCID,Yates Nicole9ORCID,Hural John3,Isaacs Abby3ORCID,Phogat Sanjay10,DiazGranados Carlos A.10,Lee Carter11,Sinangil Faruk11,Michael Nelson L.12ORCID,Robb Merlin L.12ORCID,Kublin James G.3ORCID,Gilbert Peter B.3ORCID,McElrath M. Juliana3ORCID,Tomaras Georgia D.9,Corey Lawrence3ORCID

Affiliation:

1. Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 1864, South Africa.

2. South African Medical Research Council, Cape Town 7505, South Africa.

3. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

4. The Desmond Tutu HIV Centre, University of Cape Town, Cape Town 8001, South Africa.

5. Cape Town HVTN Immunology Laboratory, Hutchinson Centre Research Institute of South Africa, Cape Town 8001, South Africa.

6. Vaccine Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA.

7. The Aurum Institute, Klerksdorp 2570, South Africa.

8. National Institute for Communicable Diseases, National Health Laboratory Service, Sandringham, Johannesburg 2192, South Africa.

9. Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

10. Sanofi Pasteur, Swiftwater, PA 18370, USA.

11. Global Solutions for Infectious Diseases, South San Francisco, CA 94080, USA.

12. US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Abstract

In South Africans, the RV144 HIV vaccine regimen elicited robust immune responses that have been associated with vaccine efficacy.

Funder

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

James B. Pendleton Charitable Trust

South African Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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