Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion-Reference-Cited by-同舟云学术

Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion

Published:2020-11-11 Issue:569 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ham Sangwoo¹²^ORCID,Yun Seung Pil³⁴,Kim Hyojung¹^ORCID,Kim Donghoon³⁴,Seo Bo Am³⁴^ORCID,Kim Heejeong¹^ORCID,Shin Jeong-Yong¹^ORCID,Dar Mohamad Aasif³⁴,Lee Gum Hwa⁵,Lee Yun Il⁶⁷,Kim Doyeun⁸⁹,Kim Sunghoon⁸⁹,Kweon Hee-Seok¹⁰,Shin Joo-Ho¹^ORCID,Ko Han Seok³⁴^ORCID,Lee Yunjong¹^ORCID

Affiliation:

1. Division of Pharmacology, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute (SBRI), Suwon 16419, Republic of Korea.

2. ToolGen Inc., Seoul 08501, Republic of Korea.

3. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4. Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

5. College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea.

6. Well Aging Research Center, DGIST, Daegu 42988, Republic of Korea.

7. Companion Diagnostics and Medical Technology Research Group, DGIST, Daegu 42988, Republic of Korea.

8. Medicinal Bioconvergence Research Center, Yonsei University, Incheon 21983, Republic of Korea.

9. College of Pharmacy and School of Medicine, Yonsei University, Incheon 21983, Republic of Korea.

10. Center for Research Equipment, Korea Basic Science Institute, Cheongju 28119, Republic of Korea.

Abstract

Pathological AIMP2 aggregation leads to α-synuclein inclusion and dopaminergic toxicity in Parkinson’s disease.

Funder

National Institute of Neurological Disorders and Stroke

National Research Foundation of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference60 articles.

1. The α-Synucleinopathies: Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy

2. Parkinson's Disease

3. Parkinson's Disease

4. α-Synuclein: Normal Function and Role in Neurodegenerative Diseases

5. Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration

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